/* Insight Rx design system: clinical instrument. Tokens first; components reference tokens only. */
@font-face {
  font-family: "Public Sans";
  src: url("/static/fonts/PublicSans.woff2") format("woff2");
  font-weight: 400 700;
  font-display: swap;
}

:root {
  --ink: #16232e;
  --ink-2: #3d4d5a;
  --ink-3: #66788a;
  --paper: #f3f6f8;
  --panel: #ffffff;
  --line: #dce3e8;
  --line-2: #eaeff2;
  --blue: #1d5fa8;
  --blue-ink: #154a85;
  --blue-wash: #e8f0f9;
  --fundus: #e0782b;
  --fundus-wash: #fdf0e5;
  --signal: #b3261e;
  --signal-wash: #fceeed;
  --clear: #1f7a4d;
  --clear-wash: #e9f5ef;
  --caution: #8a5a00;
  --caution-wash: #fdf4e1;
  --neutral: #52636f;
  --neutral-wash: #eef2f4;
  --research: #5a4a9e;
  --research-wash: #f1eefa;

  --r-sm: 6px;
  --r: 10px;
  --shadow: 0 1px 2px rgba(22, 35, 46, .06), 0 2px 8px rgba(22, 35, 46, .04);
  --s1: 4px; --s2: 8px; --s3: 12px; --s4: 16px; --s5: 24px; --s6: 32px; --s7: 48px;
  --t-xs: .75rem; --t-sm: .8125rem; --t-base: .9375rem; --t-md: 1.0625rem; --t-lg: 1.375rem; --t-xl: 1.875rem; --t-2xl: 2.5rem;
  --side: 232px;
}

*, *::before, *::after { box-sizing: border-box; }
[hidden] { display: none !important; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0; background: var(--paper); color: var(--ink);
  font: 400 var(--t-base)/1.5 "Public Sans", system-ui, -apple-system, "Segoe UI", sans-serif;
  font-variant-numeric: tabular-nums;
  -webkit-font-smoothing: antialiased;
}
h1, h2, h3, h4 { margin: 0; line-height: 1.2; font-weight: 650; letter-spacing: -.01em; }
h1 { font-size: var(--t-xl); }
h2 { font-size: var(--t-md); }
h3 { font-size: var(--t-base); }
p { margin: 0; }
a { color: var(--blue); text-decoration-thickness: 1px; text-underline-offset: 2px; }
a:hover { color: var(--blue-ink); }
img { max-width: 100%; display: block; }
:focus-visible { outline: 3px solid var(--blue); outline-offset: 2px; border-radius: 4px; }
.sr-only { position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; border: 0; }
.skip { position: absolute; left: -999px; top: 8px; background: var(--panel); padding: 8px 12px; z-index: 20; }
.skip:focus { left: 8px; }
.ico { width: 18px; height: 18px; flex: none; fill: none; stroke: currentColor; stroke-width: 1.75; stroke-linecap: round; stroke-linejoin: round; vertical-align: -3px; }
.ico-sm { width: 15px; height: 15px; }
.muted { color: var(--ink-3); }
.small { font-size: var(--t-sm); }
.xs { font-size: var(--t-xs); }
.num { font-variant-numeric: tabular-nums; }
.row { display: flex; align-items: center; gap: var(--s2); flex-wrap: wrap; }
.row-between { display: flex; align-items: center; justify-content: space-between; gap: var(--s3); flex-wrap: wrap; }
.stack > * + * { margin-top: var(--s3); }
.stack-lg > * + * { margin-top: var(--s5); }
.grid-2 { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: var(--s4); }
.grid-3 { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: var(--s4); }
.grid-4 { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: var(--s4); }

/* ------------------------------------------------------------------ shell */
.shell { display: grid; grid-template-columns: var(--side) minmax(0, 1fr); min-height: 100vh; }
.side {
  position: sticky; top: 0; height: 100vh; background: var(--ink); color: #c9d4dc;
  display: flex; flex-direction: column; padding: var(--s4) var(--s3);
}
.brand { display: flex; align-items: center; gap: 10px; color: #fff; text-decoration: none; padding: var(--s2); font-weight: 700; font-size: 1.15rem; letter-spacing: -.01em; }
.brand svg { width: 28px; height: 28px; }
.brand:hover { color: #fff; }
.nav { margin-top: var(--s5); display: grid; gap: 2px; }
.nav a {
  display: flex; align-items: center; gap: 10px; padding: 9px 10px; border-radius: var(--r-sm);
  color: #c9d4dc; text-decoration: none; font-weight: 500;
}
.nav a:hover { background: rgba(255, 255, 255, .06); color: #fff; }
.nav a[aria-current="page"] { background: rgba(255, 255, 255, .1); color: #fff; box-shadow: inset 3px 0 0 var(--fundus); }
.nav .count { margin-left: auto; background: var(--fundus); color: #fff; border-radius: 999px; font-size: var(--t-xs); padding: 0 7px; font-weight: 650; }
.side-foot { margin-top: auto; border-top: 1px solid rgba(255, 255, 255, .1); padding-top: var(--s3); display: grid; gap: var(--s2); }
.who { display: flex; gap: 10px; align-items: center; padding: var(--s2); }
.avatar {
  width: 32px; height: 32px; border-radius: 50%; display: grid; place-items: center; flex: none;
  background: #2c4254; color: #fff; font-weight: 650; font-size: var(--t-sm);
}
.avatar.lg { width: 40px; height: 40px; font-size: var(--t-base); }
.who .name { color: #fff; font-weight: 600; font-size: var(--t-sm); line-height: 1.25; }
.who .role { font-size: var(--t-xs); color: #9fb0bd; }
.side-foot a { color: #c9d4dc; font-size: var(--t-sm); text-decoration: none; display: flex; gap: 8px; align-items: center; padding: 6px var(--s2); border-radius: var(--r-sm); }
.side-foot a:hover { background: rgba(255, 255, 255, .06); color: #fff; }

.main { min-width: 0; }
.topbar {
  position: sticky; top: 0; z-index: 5; background: rgba(243, 246, 248, .92); backdrop-filter: blur(6px);
  border-bottom: 1px solid var(--line); padding: 10px var(--s6); display: flex; align-items: center; gap: var(--s3);
}
.crumbs { font-size: var(--t-sm); color: var(--ink-3); display: flex; gap: 6px; align-items: center; min-width: 0; }
.crumbs a { color: var(--ink-3); text-decoration: none; }
.crumbs a:hover { color: var(--ink); }
.topbar .right { margin-left: auto; display: flex; gap: var(--s3); align-items: center; }
.content { padding: var(--s5) var(--s6) var(--s7); max-width: 1440px; }
.disclaimer { font-size: var(--t-xs); color: var(--ink-3); padding: 0 var(--s6) var(--s5); max-width: 1440px; }

/* status of the model service */
.svc { display: inline-flex; align-items: center; gap: 6px; font-size: var(--t-xs); font-weight: 600; padding: 4px 10px; border-radius: 999px; border: 1px solid; }
.svc::before { content: ""; width: 7px; height: 7px; border-radius: 50%; background: currentColor; }
.svc.live { color: var(--clear); border-color: #b9dcc9; background: var(--clear-wash); }
.svc.simulated { color: var(--caution); border-color: #ecd49b; background: var(--caution-wash); }
.bell { position: relative; color: var(--ink-2); display: inline-grid; place-items: center; width: 36px; height: 36px; border-radius: 50%; }
.bell:hover { background: var(--line-2); color: var(--ink); }
.bell .dot { position: absolute; top: 5px; right: 5px; min-width: 16px; height: 16px; padding: 0 4px; border-radius: 999px; background: var(--signal); color: #fff; font-size: 10px; font-weight: 700; display: grid; place-items: center; }

/* ------------------------------------------------------------------ page head */
.head { display: flex; align-items: flex-end; justify-content: space-between; gap: var(--s4); flex-wrap: wrap; margin-bottom: var(--s5); }
.head .sub { color: var(--ink-3); margin-top: 6px; }
.eyebrow { font-size: var(--t-sm); color: var(--ink-3); margin-bottom: 4px; }

/* ------------------------------------------------------------------ surfaces */
.panel { background: var(--panel); border: 1px solid var(--line); border-radius: var(--r); box-shadow: var(--shadow); }
.panel-pad { padding: var(--s5); }
.panel-head { display: flex; align-items: center; justify-content: space-between; gap: var(--s3); padding: var(--s4) var(--s5); border-bottom: 1px solid var(--line-2); }
.panel-head .hint { font-size: var(--t-sm); color: var(--ink-3); }
.panel-body { padding: var(--s4) var(--s5) var(--s5); }
.section-title { font-size: var(--t-sm); font-weight: 650; color: var(--ink-2); margin: var(--s5) 0 var(--s2); }
.divider { border: 0; border-top: 1px solid var(--line-2); margin: var(--s4) 0; }

/* ------------------------------------------------------------------ buttons */
.btn {
  display: inline-flex; align-items: center; justify-content: center; gap: 8px; min-height: 38px;
  padding: 8px 16px; border-radius: var(--r-sm); border: 1px solid var(--blue); background: var(--blue);
  color: #fff; font: inherit; font-weight: 600; font-size: var(--t-sm); text-decoration: none; cursor: pointer;
  transition: background .12s, border-color .12s, box-shadow .12s;
}
.btn:hover { background: var(--blue-ink); border-color: var(--blue-ink); color: #fff; }
.btn:disabled, .btn[aria-disabled="true"] { opacity: .55; cursor: not-allowed; }
.btn.quiet { background: var(--panel); color: var(--ink); border-color: var(--line); }
.btn.quiet:hover { background: var(--line-2); color: var(--ink); }
.btn.danger { background: var(--panel); color: var(--signal); border-color: #efc6c3; }
.btn.danger:hover { background: var(--signal-wash); }
.btn.sm { min-height: 30px; padding: 4px 10px; font-size: var(--t-xs); }
.btn.lg { min-height: 46px; padding: 10px 22px; font-size: var(--t-base); }
.btn.block { width: 100%; }
.btn .spin { display: none; width: 16px; height: 16px; border: 2px solid rgba(255, 255, 255, .45); border-top-color: #fff; border-radius: 50%; animation: spin .8s linear infinite; }
.btn.busy .spin { display: inline-block; }
.btn.busy .ico { display: none; }
@keyframes spin { to { transform: rotate(360deg); } }

/* ------------------------------------------------------------------ forms */
.field { display: grid; gap: 6px; }
.field > label, .label { font-size: var(--t-sm); font-weight: 600; color: var(--ink-2); }
.field .help { font-size: var(--t-xs); color: var(--ink-3); }
input[type=text], input[type=number], input[type=date], input[type=time], input:not([type]), select, textarea {
  width: 100%; font: inherit; color: var(--ink); background: var(--panel); border: 1px solid #c7d2da;
  border-radius: var(--r-sm); padding: 8px 10px; min-height: 38px;
}
textarea { resize: vertical; min-height: 76px; }
select, input[type=text], input[type=number], input[type=date], input[type=time], input:not([type]) { height: 40px; padding-top: 6px; padding-bottom: 6px; line-height: 1.3; }
.imgmeta select { height: 30px; }
input:focus, select:focus, textarea:focus { outline: none; border-color: var(--blue); box-shadow: 0 0 0 3px var(--blue-wash); }
fieldset { border: 0; padding: 0; margin: 0; min-width: 0; }
legend { font-size: var(--t-sm); font-weight: 600; color: var(--ink-2); margin-bottom: 8px; padding: 0; }
.choice { display: flex; gap: 10px; align-items: flex-start; padding: 10px 12px; border: 1px solid var(--line); border-radius: var(--r-sm); cursor: pointer; background: var(--panel); }
.choice:hover { border-color: #b7c4ce; }
.choice:has(input:checked) { border-color: var(--blue); background: var(--blue-wash); }
.choice input { margin-top: 3px; accent-color: var(--blue); }
.choice .t { font-weight: 600; font-size: var(--t-sm); }
.choice .d { font-size: var(--t-xs); color: var(--ink-3); }
.choices { display: grid; gap: 8px; }
.check { display: flex; gap: 10px; align-items: flex-start; font-size: var(--t-sm); }
.check input { margin-top: 3px; accent-color: var(--blue); width: 16px; height: 16px; }
.seg { display: inline-flex; border: 1px solid #c7d2da; border-radius: var(--r-sm); overflow: hidden; background: var(--panel); }
.seg label { padding: 7px 12px; font-size: var(--t-sm); cursor: pointer; border-left: 1px solid var(--line); }
.seg label:first-child { border-left: 0; }
.seg input { position: absolute; opacity: 0; pointer-events: none; }
.seg label:has(input:checked) { background: var(--ink); color: #fff; }
.seg label:has(input:focus-visible) { outline: 3px solid var(--blue); outline-offset: -3px; }
.seg a { padding: 6px 12px; font-size: var(--t-sm); color: var(--ink-2); text-decoration: none; border-left: 1px solid var(--line); }
.seg a:first-child { border-left: 0; }
.seg a:hover { background: var(--line-2); color: var(--ink); }
.seg a[aria-current="page"] { background: var(--ink); color: #fff; }

/* ------------------------------------------------------------------ tags (status never by colour alone) */
.tag { display: inline-flex; align-items: center; gap: 5px; font-size: var(--t-xs); font-weight: 600; padding: 3px 9px; border-radius: 999px; background: var(--neutral-wash); color: var(--neutral); white-space: nowrap; }
.tag .ico { width: 13px; height: 13px; vertical-align: 0; }
.tag.signal { background: var(--signal-wash); color: var(--signal); }
.tag.clear { background: var(--clear-wash); color: var(--clear); }
.tag.caution { background: var(--caution-wash); color: var(--caution); }
.tag.info { background: var(--blue-wash); color: var(--blue-ink); }
.tag.research { background: var(--research-wash); color: var(--research); }
.tag.hcp { background: #e6f4f6; color: #0f5e69; }
.tag.outline { background: transparent; border: 1px solid var(--line); color: var(--ink-2); }

/* ------------------------------------------------------------------ tables */
.table { width: 100%; border-collapse: collapse; font-size: var(--t-sm); }
.table th { text-align: left; font-weight: 600; color: var(--ink-3); padding: 10px var(--s4); border-bottom: 1px solid var(--line); white-space: nowrap; }
.table td { padding: 12px var(--s4); border-bottom: 1px solid var(--line-2); vertical-align: middle; }
.table tr:last-child td { border-bottom: 0; }
.table tbody tr:hover { background: #f8fafb; }
.table .primary { font-weight: 600; color: var(--ink); text-decoration: none; white-space: nowrap; }
.table .primary:hover { color: var(--blue); }
.table-wrap { overflow-x: auto; }

/* ------------------------------------------------------------------ stats */
.stat { padding: var(--s4) var(--s5); }
.stat .k { font-size: var(--t-sm); color: var(--ink-3); }
.stat .v { font-size: var(--t-xl); font-weight: 650; margin-top: 2px; letter-spacing: -.02em; }
.stat .d { font-size: var(--t-xs); color: var(--ink-3); margin-top: 2px; }

/* ------------------------------------------------------------------ relay: who holds the case */
.relay { display: flex; align-items: stretch; gap: 0; overflow-x: auto; padding: 2px; }
.leg { display: flex; align-items: center; gap: 10px; padding: 8px 14px 8px 10px; position: relative; flex: none; }
.relay { list-style: none; margin: 0; }
.leg + .leg::before { content: ""; width: 28px; height: 2px; background: var(--line); margin-right: 6px; flex: none; }
.leg.done + .leg::before { background: #a9c9b8; }
.leg .avatar { background: var(--line-2); color: var(--ink-2); }
.leg.done .avatar { background: var(--clear-wash); color: var(--clear); }
.leg.now .avatar { background: var(--fundus); color: #fff; box-shadow: 0 0 0 4px var(--fundus-wash); }
.leg .n { font-weight: 600; font-size: var(--t-sm); white-space: nowrap; }
.leg .r { font-size: var(--t-xs); color: var(--ink-3); white-space: nowrap; }
.leg.now .r { color: #a24c10; font-weight: 600; }

/* ------------------------------------------------------------------ tabs */
.tabs { display: flex; gap: 4px; border-bottom: 1px solid var(--line); margin-bottom: var(--s5); overflow-x: auto; }
.tabs a { padding: 10px 14px; color: var(--ink-3); text-decoration: none; font-weight: 600; font-size: var(--t-sm); border-bottom: 2px solid transparent; margin-bottom: -1px; white-space: nowrap; display: flex; gap: 6px; align-items: center; }
.tabs a:hover { color: var(--ink); }
.tabs a[aria-current="page"] { color: var(--ink); border-color: var(--ink); }
.tabs .badge { background: var(--line-2); color: var(--ink-2); border-radius: 999px; padding: 0 7px; font-size: var(--t-xs); }

/* ------------------------------------------------------------------ fundus viewer */
.workspace { display: grid; grid-template-columns: minmax(0, 1fr) 380px; gap: var(--s5); align-items: start; }
.eyes { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: var(--s4); }
.eye-col .eye-head { display: flex; align-items: center; justify-content: space-between; gap: var(--s2); margin-bottom: var(--s2); }
.eye-col .eye-head h3 { font-size: var(--t-sm); }
.fundus { position: relative; background: #05080b; border-radius: var(--r); overflow: hidden; aspect-ratio: 1; }
.fundus img { position: absolute; inset: 0; width: 100%; height: 100%; object-fit: contain; }
.fundus .overlay { opacity: 0; transition: opacity .15s; pointer-events: none; }
.fundus.show-attn .overlay { opacity: var(--attn, .85); }
.fundus .corner { position: absolute; left: 10px; top: 10px; display: flex; gap: 6px; }
.fundus .corner .tag { background: rgba(5, 8, 11, .7); color: #fff; }
.fundus .corner .tag.signal { background: var(--signal); color: #fff; }
.fundus .corner .tag.clear { background: var(--clear); color: #fff; }
.fundus .corner .tag.caution { background: #b07400; color: #fff; }
.fundus.empty { display: grid; place-items: center; color: #8ea0ad; font-size: var(--t-sm); border: 1px dashed #b7c4ce; background: #eef2f4; }
.viewbar { display: flex; align-items: center; gap: var(--s2); margin-top: 8px; flex-wrap: wrap; font-size: var(--t-xs); color: var(--ink-3); }
.viewbar input[type=range] { width: 110px; accent-color: var(--fundus); }
.thumbs { display: flex; gap: 6px; margin-top: 8px; flex-wrap: wrap; }
.thumbs button { width: 58px; height: 58px; padding: 0; border-radius: var(--r-sm); border: 2px solid transparent; background: #05080b; cursor: pointer; overflow: hidden; position: relative; }
.thumbs button[aria-pressed="true"] { border-color: var(--fundus); }
.thumbs img { width: 100%; height: 100%; object-fit: cover; }
.thumbs .q { position: absolute; bottom: 2px; right: 2px; width: 10px; height: 10px; border-radius: 50%; border: 2px solid #fff; }
.q.assessable { background: var(--clear); } .q.uncertain { background: #d99a00; } .q.unassessable, .q.unsupported { background: var(--signal); }
.imgmeta { font-size: var(--t-xs); color: var(--ink-3); margin-top: 8px; display: grid; gap: 4px; }
.imgmeta form { display: inline-flex; gap: 6px; align-items: center; }
.imgmeta select { min-height: 28px; padding: 2px 6px; width: auto; font-size: var(--t-xs); }

/* verdict */
.verdict { border-radius: var(--r); padding: var(--s5); border: 1px solid var(--line); background: var(--panel); }
.verdict .state { display: flex; align-items: center; gap: 10px; font-size: var(--t-lg); font-weight: 700; letter-spacing: -.01em; }
.verdict .state .ico { width: 26px; height: 26px; stroke-width: 2; }
.verdict.signal { border-color: #efc6c3; background: linear-gradient(0deg, var(--panel) 60%, var(--signal-wash)); }
.verdict.signal .state { color: var(--signal); }
.verdict.clear { border-color: #b9dcc9; background: linear-gradient(0deg, var(--panel) 60%, var(--clear-wash)); }
.verdict.clear .state { color: var(--clear); }
.verdict.caution { border-color: #ecd49b; background: linear-gradient(0deg, var(--panel) 60%, var(--caution-wash)); }
.verdict.caution .state { color: var(--caution); }
.verdict .explain { margin-top: 8px; color: var(--ink-2); font-size: var(--t-sm); }
.facts { display: grid; grid-template-columns: auto 1fr; gap: 6px 14px; font-size: var(--t-sm); margin: 0; }
.facts dt { color: var(--ink-3); }
.facts dd { margin: 0; font-weight: 500; overflow-wrap: anywhere; }

/* bullet gauge: score vs frozen threshold */
.gauge { margin-top: var(--s2); }
.gauge .track { position: relative; height: 10px; background: var(--line-2); border-radius: 999px; }
.gauge .fill { position: absolute; left: 0; top: 0; bottom: 0; border-radius: 999px; background: var(--ink-3); }
.gauge.signal .fill { background: var(--signal); }
.gauge.clear .fill { background: var(--clear); }
.gauge .thr { position: absolute; top: -4px; bottom: -4px; width: 2px; background: var(--ink); }
.gauge .lbl { display: flex; justify-content: space-between; font-size: var(--t-xs); color: var(--ink-3); margin-top: 4px; }
.probs { display: grid; gap: 4px; margin-top: 6px; }
.probs .p { display: grid; grid-template-columns: 110px 1fr 40px; gap: 8px; align-items: center; font-size: var(--t-xs); }
.probs .bar { height: 8px; background: var(--line-2); border-radius: 999px; overflow: hidden; }
.probs .bar span { display: block; height: 100%; background: var(--blue); border-radius: 999px; }

/* diverging contribution bars (neutral midpoint) */
.contrib { display: grid; gap: 5px; }
.contrib .c { display: grid; grid-template-columns: 150px 1fr 52px; gap: 8px; align-items: center; font-size: var(--t-xs); }
.contrib .axis { position: relative; height: 10px; background: var(--line-2); border-radius: 3px; }
.contrib .axis::after { content: ""; position: absolute; left: 50%; top: -3px; bottom: -3px; width: 1px; background: var(--ink-3); }
.contrib .up, .contrib .down { position: absolute; top: 0; bottom: 0; }
.contrib .up { left: 50%; background: #c2553a; border-radius: 0 3px 3px 0; }
.contrib .down { right: 50%; background: #3d7ca8; border-radius: 3px 0 0 3px; }

/* ------------------------------------------------------------------ dropzone */
.drop { border: 1.5px dashed #b7c4ce; border-radius: var(--r); padding: var(--s5); text-align: center; background: #f8fafb; transition: border-color .12s, background .12s; }
.drop.over { border-color: var(--blue); background: var(--blue-wash); }
.drop .big { font-weight: 600; margin-top: 6px; }
.previews { display: flex; flex-wrap: wrap; gap: 8px; margin-top: var(--s3); justify-content: center; }
.previews figure { margin: 0; width: 84px; font-size: 10px; color: var(--ink-3); }
.previews img { width: 84px; height: 84px; object-fit: cover; border-radius: var(--r-sm); background: #05080b; }

/* ------------------------------------------------------------------ timeline */
.timeline { list-style: none; margin: 0; padding: 0; position: relative; }
.timeline li { position: relative; padding: 0 0 var(--s4) 28px; }
.timeline li::before { content: ""; position: absolute; left: 7px; top: 18px; bottom: 0; width: 2px; background: var(--line); }
.timeline li:last-child::before { display: none; }
.timeline .pip { position: absolute; left: 0; top: 4px; width: 16px; height: 16px; border-radius: 50%; background: var(--panel); border: 2px solid var(--ink-3); }
.timeline .pip.done { border-color: var(--clear); background: var(--clear); }
.timeline .pip.now { border-color: var(--fundus); background: var(--fundus); box-shadow: 0 0 0 4px var(--fundus-wash); }
.timeline .when { font-size: var(--t-xs); color: var(--ink-3); }
.timeline .what { font-size: var(--t-sm); }

/* ------------------------------------------------------------------ messages / toasts / empty */
.toast { display: flex; align-items: center; gap: 10px; padding: 10px 14px; border-radius: var(--r-sm); background: var(--ink); color: #fff; font-size: var(--t-sm); margin-bottom: var(--s4); }
.toast.warn { background: var(--caution-wash); color: var(--caution); border: 1px solid #ecd49b; }
.note { padding: 12px 14px; border-radius: var(--r-sm); background: var(--neutral-wash); font-size: var(--t-sm); color: var(--ink-2); display: flex; gap: 10px; align-items: flex-start; }
.note.warn { background: var(--caution-wash); color: #6a4600; }
.note.signal { background: var(--signal-wash); color: #7d1b15; }
.note .ico { margin-top: 1px; }
.empty { text-align: center; padding: var(--s6) var(--s4); color: var(--ink-3); }
.empty .ico { width: 30px; height: 30px; color: #9aabb8; }
.empty p { margin-top: 8px; }
.msg { border-left: 3px solid var(--line); padding: 4px 0 4px 12px; }
.msg.response { border-color: var(--clear); }
.msg.info_request { border-color: #d99a00; }
.msg.decline { border-color: var(--signal); }
.msg .meta { font-size: var(--t-xs); color: var(--ink-3); }
.package { font-size: var(--t-sm); }
.package li { margin-bottom: 6px; }
.package .src { color: var(--ink-3); font-size: var(--t-xs); }
.next-action { border: 1px solid #f2c9a6; background: var(--fundus-wash); border-radius: var(--r); padding: var(--s4) var(--s5); }
.next-action h2 { font-size: var(--t-base); color: #7a3a0c; display: flex; gap: 8px; align-items: center; }

/* ------------------------------------------------------------------ bar lists (funnel etc.) */
.bars { display: grid; gap: 10px; }
.bars .b { display: grid; grid-template-columns: 150px 1fr 44px; gap: 12px; align-items: center; font-size: var(--t-sm); }
.bars .t { height: 14px; background: var(--line-2); border-radius: 0 4px 4px 0; }
.bars .t span { display: block; height: 100%; background: var(--blue); border-radius: 0 4px 4px 0; min-width: 2px; }

/* ------------------------------------------------------------------ landing / sign-in */
.landing { min-height: 100vh; display: grid; grid-template-columns: minmax(0, 1.05fr) minmax(0, 1fr); }
.landing .story { background: var(--ink); color: #dbe4ea; padding: var(--s7) clamp(24px, 5vw, 72px); display: flex; flex-direction: column; gap: var(--s6); }
.landing .story h1 { color: #fff; font-size: clamp(2rem, 1.2rem + 2.4vw, 3rem); line-height: 1.08; letter-spacing: -.025em; max-width: 16ch; }
.landing .story .lede { font-size: var(--t-md); max-width: 46ch; color: #b7c5cf; }
.loop { display: grid; gap: 0; max-width: 520px; }
.loop .step { display: grid; grid-template-columns: 40px 1fr; gap: 14px; position: relative; padding-bottom: 18px; }
.loop .step::before { content: ""; position: absolute; left: 19px; top: 40px; bottom: 0; width: 2px; background: #2f4557; }
.loop .step:last-child::before { display: none; }
.loop .dot { width: 40px; height: 40px; border-radius: 50%; display: grid; place-items: center; background: #22384a; color: #fff; }
.loop .step:first-child .dot { background: var(--fundus); }
.loop .t { color: #fff; font-weight: 600; }
.loop .d { font-size: var(--t-sm); color: #9fb0bd; }
.landing .pick { padding: var(--s7) clamp(24px, 4vw, 56px); display: flex; flex-direction: column; gap: var(--s5); }
.people { display: grid; gap: 8px; }
.person { display: flex; align-items: center; gap: 12px; width: 100%; padding: 12px 14px; background: var(--panel); border: 1px solid var(--line); border-radius: var(--r); cursor: pointer; font: inherit; color: inherit; text-align: left; }
.person:hover { border-color: var(--blue); box-shadow: 0 0 0 3px var(--blue-wash); }
.person .n { font-weight: 600; }
.person .r { font-size: var(--t-sm); color: var(--ink-3); }
.person .go { margin-left: auto; color: var(--ink-3); }
.person.suggested { border-color: #f2c9a6; }
.tour { font-size: var(--t-sm); color: var(--ink-2); background: var(--panel); border: 1px solid var(--line); border-radius: var(--r); padding: var(--s4) var(--s5); }
.tour ol { margin: 8px 0 0; padding-left: 20px; display: grid; gap: 4px; }


/* ------------------------------------------------------------------ oculomics: body map, retina, evidence */
:root { --known: #c98a1b; --unknown-sw: #cbd5dc; }
.oc-grid { display: grid; grid-template-columns: minmax(260px, .9fr) minmax(0, 1.3fr); gap: var(--s5); align-items: start; }
.oc-patient .oc-grid { gap: 0; }
.oc-patient .oc-map { border-right: 1px solid var(--line-2); }
.bodymap { width: 100%; max-width: 320px; display: block; margin: var(--s3) auto 0; overflow: visible; }
.bodymap .figure circle, .bodymap .figure path:not(.limb) { fill: #e6edf1; stroke: #d2dce3; stroke-width: 1.5; }
.bodymap .limb { fill: none; stroke: #e6edf1; stroke-width: 24; stroke-linecap: round; }
.bodymap .leg { stroke-width: 28; }
.bodymap .window { fill: none; stroke: #c3cfd8; stroke-width: 1.5; stroke-dasharray: 4 5; animation: flow 1.8s linear infinite; }
.bodymap .window.signal { stroke: var(--signal); stroke-opacity: .7; }
.bodymap .window.recorded { stroke: var(--known); stroke-opacity: .8; }
.bodymap .window.clear { stroke: var(--clear); stroke-opacity: .55; }
.bodymap .window.na { stroke-opacity: .5; animation: none; }
.bodymap .window.hl { stroke: var(--fundus); stroke-width: 2.6; stroke-opacity: 1; }
@keyframes flow { to { stroke-dashoffset: -18; } }
.bodymap .glow { transform-box: fill-box; transform-origin: center; animation: pulse 2.6s ease-in-out infinite; }
@keyframes pulse { 0%, 100% { transform: scale(.8); opacity: .6; } 50% { transform: scale(1.15); opacity: 1; } }
.bodymap .node circle { stroke: #fff; stroke-width: 3; transition: stroke .15s, stroke-width .15s; }
.bodymap .node text { fill: #fff; font: 700 12px "Public Sans", sans-serif; }
.bodymap .node .tick { fill: none; stroke: #fff; stroke-width: 2.4; stroke-linecap: round; stroke-linejoin: round; }
.bodymap .node.signal circle { fill: var(--signal); }
.bodymap .node.recorded circle { fill: var(--known); }
.bodymap .node.exploratory circle { fill: var(--research); }
.bodymap .window.exploratory { stroke: var(--research); stroke-opacity: .6; }
.bodymap .node.clear circle { fill: var(--clear); }
.bodymap .node.unknown circle { fill: #fff; stroke: #8a9aa6; stroke-width: 2; }
.bodymap .node.unknown text { fill: var(--ink); }
.bodymap .node.na circle { fill: #eef2f4; stroke: #aab8c3; stroke-width: 1.5; stroke-dasharray: 3 2; }
.bodymap .node.na text { fill: var(--ink-3); }
.bodymap .node.hl circle { stroke: var(--fundus); stroke-width: 4; }
.bodymap .lbl { font: 600 11px "Public Sans", sans-serif; fill: var(--ink-2); }
.legend { list-style: none; padding: 0; margin: var(--s3) 0 0; display: flex; flex-wrap: wrap; gap: 6px 14px; font-size: var(--t-xs); color: var(--ink-2); justify-content: center; }
.legend li { display: inline-flex; align-items: center; gap: 6px; }
.sw { width: 11px; height: 11px; border-radius: 50%; display: inline-block; }
.sw.signal { background: var(--signal); } .sw.exploratory { background: var(--research); } .sw.recorded { background: var(--known); } .sw.clear { background: var(--clear); }
.sw.unknown { background: #fff; border: 2px solid #8a9aa6; } .sw.na { background: #eef2f4; border: 1.5px dashed #aab8c3; }
.organs { list-style: none; margin: 0; padding: 0; }
.organs li { padding: 12px var(--s2); border-bottom: 1px solid var(--line-2); border-radius: var(--r-sm); outline-offset: -2px; transition: background .15s; }
.organs li:last-child { border-bottom: 0; }
.organs li:hover, .organs li.hl { background: var(--fundus-wash); }
.organs li p { margin-top: 3px; }
.stackbar { display: flex; height: 10px; border-radius: 999px; overflow: hidden; background: var(--line-2); margin-top: 8px; gap: 2px; }
.stackbar span { display: block; height: 100%; }
.seg-signal { background: var(--signal); } .seg-exploratory { background: var(--research); } .seg-recorded { background: var(--known); } .seg-unknown { background: var(--unknown-sw); } .seg-clear { background: var(--clear); }
.counts { display: flex; flex-wrap: wrap; gap: 4px 14px; color: var(--ink-3); margin-top: 6px; }
.tier { display: inline-flex; align-items: center; font-size: var(--t-xs); font-weight: 650; padding: 2px 9px; border-radius: 999px; white-space: nowrap; }
.tier.established { background: var(--clear-wash); color: var(--clear); }
.tier.research { background: var(--caution-wash); color: var(--caution); }
.tier.evaluating { background: var(--neutral-wash); color: var(--neutral); }
.tier.exploratory { background: var(--research-wash); color: var(--research); }
.tier.future { border: 1px dashed #aab8c3; color: var(--ink-3); }

.oc-hero { overflow: hidden; background: linear-gradient(180deg, #fff, #f7f9fb); }
.oc-hero-in { display: grid; grid-template-columns: minmax(0, 1fr) minmax(0, 1.1fr) minmax(0, .9fr); gap: var(--s5); padding: var(--s6) var(--s5); align-items: center; }
.retina { width: 100%; max-width: 300px; display: block; margin: 0 auto; border-radius: 16px; box-shadow: 0 12px 32px rgba(22, 35, 46, .18); }
.retina .feat { transition: opacity .2s, filter .2s; }
.retina [data-f="vessels"] path { fill: none; stroke: #7a1c0e; stroke-width: 3.4; stroke-linecap: round; }
.retina [data-f="vessels"] .thin { stroke-width: 1.8; }
.retina [data-f="lesions"] circle { fill: #6e0c08; } .retina .haem { fill: #8d140c; } .retina .exud { fill: #f4d37a !important; }
.retina.focus .feat { opacity: .22; }
.retina.focus .feat.hl { opacity: 1; filter: drop-shadow(0 0 5px #ffe2b8); }
.features { list-style: none; margin: 0; padding: 0; display: grid; gap: 8px; }
.features li { display: grid; gap: 2px; padding: 10px 12px; border-left: 3px solid var(--line); border-radius: 0 var(--r-sm) var(--r-sm) 0; cursor: default; transition: background .15s, border-color .15s; }
.features li:hover, .features li:focus, .features li.hl { border-color: var(--fundus); background: var(--fundus-wash); outline: none; }
.flow { list-style: none; margin: var(--s4) 0 0; padding: 0; display: grid; grid-template-columns: repeat(6, minmax(0, 1fr)); gap: var(--s3); }
.flow li { display: grid; gap: 4px; position: relative; font-size: var(--t-sm); }
.flow li:not(:last-child)::after { content: ""; position: absolute; top: 20px; left: 48px; right: -8px; height: 2px; background: var(--line); }
.flow .dot { width: 40px; height: 40px; border-radius: 50%; display: grid; place-items: center; background: var(--ink); color: #fff; position: relative; z-index: 1; }
.flow li:first-child .dot { background: var(--fundus); }
.refs { list-style: none; margin: 0; padding: 0; display: grid; gap: 10px; }
.refs li { display: grid; gap: 2px; }
.snapshot { display: block; text-decoration: none; color: inherit; }
.snapshot:hover { border-color: var(--fundus); color: inherit; }
.snapshot h2 { font-size: var(--t-base); }
.snapshot ul { list-style: none; margin: 10px 0 0; padding: 0; display: grid; gap: 6px; }
.snapshot li { display: grid; grid-template-columns: 12px 1fr auto; gap: 8px; align-items: center; }
.dotst { width: 10px; height: 10px; border-radius: 50%; background: #eef2f4; border: 1.5px dashed #aab8c3; }
.dotst.signal { background: var(--signal); border: 0; } .dotst.exploratory { background: var(--research); border: 0; } .dotst.recorded { background: var(--known); border: 0; }
.dotst.clear { background: var(--clear); border: 0; } .dotst.unknown { background: #fff; border: 2px solid #8a9aa6; }
@media (max-width: 1180px) { .oc-hero-in { grid-template-columns: 1fr 1fr; } .oc-hero-in .oc-col:last-child { grid-column: span 2; } .flow { grid-template-columns: repeat(3, minmax(0, 1fr)); } .flow li::after { display: none; } }
@media (max-width: 860px) { .oc-grid, .oc-hero-in { grid-template-columns: minmax(0, 1fr); } .oc-hero-in .oc-col:last-child { grid-column: auto; } .oc-patient .oc-map { border-right: 0; border-bottom: 1px solid var(--line-2); } .flow { grid-template-columns: repeat(2, minmax(0, 1fr)); } }

/* guided steps */
.steps { list-style: none; margin: 0 0 var(--s5); padding: 0; display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: var(--s3); }
.steps li { display: flex; align-items: center; gap: 10px; padding: 10px 14px; border-radius: var(--r); background: var(--panel); border: 1px solid var(--line); font-size: var(--t-sm); color: var(--ink-3); }
.steps li span { width: 26px; height: 26px; border-radius: 50%; display: grid; place-items: center; background: var(--line-2); color: var(--ink-2); font-weight: 700; flex: none; }
.steps li.now { color: var(--ink); border-color: #f2c9a6; background: var(--fundus-wash); }
.steps li.now span { background: var(--fundus); color: #fff; }
.steps li.done span { background: var(--clear); color: #fff; }
.stepno { display: inline-grid; place-items: center; width: 24px; height: 24px; border-radius: 50%; background: var(--ink); color: #fff; font-size: var(--t-xs); margin-right: 8px; vertical-align: 1px; }
.topic { display: grid; gap: 2px; padding: 8px 12px; border: 1px solid var(--line); border-radius: var(--r-sm); text-decoration: none; color: var(--ink); background: var(--panel); font-size: var(--t-sm); }
.topic span { font-size: var(--t-xs); color: var(--ink-3); }
.topic:hover { border-color: var(--blue); color: var(--ink); }
.topic.on { border-color: var(--blue); background: var(--blue-wash); box-shadow: inset 0 0 0 1px var(--blue); }
@media (max-width: 860px) { .steps { grid-template-columns: 1fr; } }

/* screen */
.summary { padding: var(--s5); }
.summary-grid { display: grid; grid-template-columns: minmax(0, 1.2fr) minmax(0, 1fr); gap: var(--s5); }
.summary-grid > div + div { border-left: 1px solid rgba(22, 35, 46, .1); padding-left: var(--s5); }
.chips { list-style: none; margin: 8px 0 0; padding: 0; display: grid; gap: 5px; font-size: var(--t-sm); }
.chips li { display: flex; align-items: center; gap: 8px; }
.actionbar { display: flex; align-items: center; gap: var(--s3); padding: var(--s3) var(--s4); flex-wrap: wrap; }
.photo-grid { display: grid; grid-template-columns: repeat(auto-fill, minmax(230px, 1fr)); gap: var(--s4); }
.photo .fundus { border-radius: var(--r-sm); }
.photo .corner { flex-wrap: wrap; }
.evi { display: grid; grid-template-columns: repeat(auto-fill, minmax(260px, 1fr)); gap: var(--s4); }
.evi article { border-left: 3px solid var(--blue); padding: 2px 0 2px 12px; display: grid; gap: 4px; }
.drop.compact { padding: var(--s3); }
.drop.compact .previews img { width: 56px; height: 56px; }
.drop.compact .previews figure { width: 56px; }
.organdots { display: flex; flex-wrap: wrap; gap: 4px 10px; font-size: var(--t-xs); color: var(--ink-2); }
.organdots .od { display: inline-flex; align-items: center; gap: 4px; white-space: nowrap; }
.side-foot a[aria-current="page"] { background: rgba(255, 255, 255, .1); color: #fff; }
@media (max-width: 860px) { .summary-grid { grid-template-columns: 1fr; } .summary-grid > div + div { border-left: 0; padding-left: 0; } }

/* clinical inputs */
.inputs { border: 1px solid var(--line); border-radius: var(--r); padding: var(--s3) var(--s4) var(--s4); }
.inputs legend { padding: 0 6px; }
.hist { display: grid; gap: 6px; }
.hist .seg label { padding: 4px 9px; font-size: var(--t-xs); }
.conds td { vertical-align: top; }
.inputs-summary { display: flex; flex-wrap: wrap; gap: 6px; }
.inputs-summary .tag.missing { border: 1px dashed #d99a00; background: var(--caution-wash); color: var(--caution); }

/* access gate */
.access { min-height: 100vh; display: grid; place-items: center; padding: var(--s5); background: radial-gradient(circle at 30% 20%, #22384a, var(--ink) 60%); }
.access form { width: min(420px, 100%); }

/* inbox: activity column */
.inbox-grid { display: grid; grid-template-columns: minmax(0, 1fr) 340px; gap: var(--s5); align-items: start; }
.inbox-side { position: sticky; top: 76px; }
.spark { width: 100%; height: 64px; display: block; margin: var(--s3) 0 4px; }
.spark rect { fill: #9bb4c9; }
.spark rect.today { fill: var(--blue); }
.spark line { stroke: var(--line); }
.feed { list-style: none; margin: 0; padding: var(--s2) var(--s5) var(--s4); display: grid; gap: 12px; }
.feed li { display: grid; grid-template-columns: 32px 1fr; gap: 10px; align-items: start; }
.feed .avatar { background: var(--line-2); color: var(--ink-2); font-size: var(--t-xs); }
.feed .avatar.me { background: var(--fundus); color: #fff; }
.feed a { color: var(--ink-2); text-decoration: none; }
.feed a:hover { color: var(--blue); text-decoration: underline; }
@media (max-width: 1180px) { .inbox-grid { grid-template-columns: minmax(0, 1fr); } .inbox-side { position: static; } }

/* landing: story panel on dark */
.kicker { color: var(--fundus); font-weight: 650; font-size: var(--t-sm); }
.proof { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: var(--s4); margin: 0; }
.proof div { border-top: 2px solid #2f4557; padding-top: 10px; }
.proof dt { color: #fff; font-size: var(--t-xl); font-weight: 700; letter-spacing: -.02em; }
.proof dd { margin: 2px 0 0; font-size: var(--t-xs); color: #9fb0bd; }
.story-grid { display: grid; grid-template-columns: minmax(180px, .8fr) minmax(0, 1fr); gap: var(--s5); align-items: center; }
.story .bodymap { max-width: 250px; margin-top: 0; }
.story .bodymap .figure circle, .story .bodymap .figure path:not(.limb) { fill: #22384a; stroke: #2f4a5f; }
.story .bodymap .limb { stroke: #22384a; }
.story .bodymap .lbl { fill: #c9d4dc; }
.story .bodymap .node circle { stroke: var(--ink); }
.story .bodymap .window { stroke: #46627a; }
@media (max-width: 860px) { .story-grid, .proof { grid-template-columns: minmax(0, 1fr); } }

/* ------------------------------------------------------------------ responsive */
@media (max-width: 1180px) {
  .workspace { grid-template-columns: minmax(0, 1fr) !important; }     /* beats per-page inline column templates */
  .grid-4 { grid-template-columns: repeat(2, minmax(0, 1fr)); }
}
@media (max-width: 860px) {
  .shell { grid-template-columns: minmax(0, 1fr); }
  .side > * { min-width: 0; }
  .head h1 { font-size: var(--t-lg); }
  .workspace aside { position: static !important; }
  .relay { flex-direction: column; padding: 4px 0; }
  .leg + .leg::before { display: none; }
  .leg { padding: 6px 8px; }
  .leg .n, .leg .r { white-space: normal; }
  .side { position: static; height: auto; flex-direction: row; flex-wrap: wrap; align-items: center; padding: var(--s2) var(--s3); gap: var(--s2); }
  .nav { margin: 0; display: flex; overflow-x: auto; width: 100%; min-width: 0; order: 3; scrollbar-width: none; }
  .nav a { white-space: nowrap; }
  .side-foot { display: none; }
  .topbar, .content { padding-left: var(--s4); padding-right: var(--s4); }
  .disclaimer { padding: 0 var(--s4) var(--s5); }
  .grid-2, .grid-3, .grid-4, .eyes { grid-template-columns: minmax(0, 1fr); }
  .landing { grid-template-columns: 1fr; }
  .bars .b, .contrib .c { grid-template-columns: 110px 1fr 44px; }
}
@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after { transition: none !important; animation: none !important; }
}

/* ------------------------------------------------------------------ therapeutics layer */
:root { --mol: #0f6b6b; --mol-wash: #e4f3f2; }
.tag.mol { background: var(--mol-wash); color: var(--mol); text-decoration: none; }
a.tag.mol:hover { background: #cfe9e7; }
.pills { list-style: none; padding: 0; margin: 0; display: flex; flex-wrap: wrap; gap: 6px 10px; }
.pills li { display: inline-flex; align-items: center; gap: 6px; font-size: var(--t-sm); padding: 4px 10px; border: 1px solid var(--line); border-radius: 999px; background: var(--panel); }

/* value chain: eye -> signal -> target -> therapy -> physician */
.chain { list-style: none; margin: 0; padding: var(--s4) var(--s5); display: grid; grid-template-columns: repeat(5, minmax(0, 1fr)); gap: var(--s3);
  background: linear-gradient(90deg, var(--fundus-wash), var(--panel) 35%, var(--panel) 65%, var(--mol-wash)); border: 1px solid var(--line); border-radius: var(--r); }
.chain li { display: grid; grid-template-columns: 36px minmax(0, 1fr); column-gap: 10px; align-items: center; position: relative; font-size: var(--t-sm); min-width: 0; padding-right: 18px; }
.chain li > * { min-width: 0; overflow-wrap: anywhere; }
.chain li .dot { grid-row: span 2; width: 36px; height: 36px; border-radius: 50%; display: grid; place-items: center; background: var(--panel); border: 1.5px solid var(--line); color: var(--ink-2); }
.chain li:first-child .dot { background: var(--fundus); border-color: var(--fundus); color: #fff; }
.chain li.on .dot { background: var(--mol); border-color: var(--mol); color: #fff; box-shadow: 0 0 0 4px var(--mol-wash); }
.chain li:not(:last-child)::after { content: "\2192"; position: absolute; right: 0; top: 50%; transform: translateY(-50%); color: var(--ink-3); }

/* medicines picker */
.medchips { display: flex; flex-wrap: wrap; gap: 6px; }
.medchip { position: relative; }
.medchip input { position: absolute; opacity: 0; inset: 0; }
.medchip span { display: inline-block; padding: 4px 10px; border-radius: 999px; border: 1px solid var(--line); font-size: var(--t-xs); background: var(--panel); cursor: pointer; transition: background .15s, border-color .15s; }
.medchip span:hover { border-color: #b7c4ce; }
.medchip input:checked + span { background: var(--mol-wash); border-color: var(--mol); color: var(--mol); font-weight: 600; }
.medchip input:focus-visible + span { outline: 3px solid var(--blue); outline-offset: 2px; }

/* therapy cards and interaction alerts */
.txlist { list-style: none; margin: 0; padding: 0; display: grid; gap: var(--s3); }
.tx { border: 1px solid var(--line); border-left: 3px solid var(--mol); border-radius: var(--r-sm); padding: var(--s4); background: var(--panel); }
.tx h3 { font-size: var(--t-md); margin-top: 2px; }
.ixlist { list-style: none; margin: var(--s3) 0 0; padding: 0; display: grid; gap: 8px; }
.ix { padding: 10px 12px; border-radius: var(--r-sm); background: var(--neutral-wash); border-left: 3px solid var(--neutral); }
.ix.major { background: var(--signal-wash); border-left-color: var(--signal); }
.ix.moderate { background: var(--caution-wash); border-left-color: #b07400; }
.tx .mi { margin-top: var(--s3); border-top: 1px dashed var(--line); padding-top: var(--s2); }
.tx .mi summary { cursor: pointer; color: var(--blue); }
.sponsored { border: 1px dashed var(--line); border-radius: var(--r-sm); padding: var(--s3) var(--s4); background: repeating-linear-gradient(135deg, #fafbfc, #fafbfc 8px, #f4f6f8 8px, #f4f6f8 16px); }

/* trials */
.trialgrp + .trialgrp { margin-top: var(--s4); padding-top: var(--s4); border-top: 1px solid var(--line-2); }
.trials { list-style: none; margin: 6px 0 0; padding: 0; display: grid; gap: 10px; }
.trials li { display: grid; gap: 2px; }
.trials a { text-decoration: none; }
.trials a:hover { text-decoration: underline; }

/* target list, explorer and viewer */
.tglist { list-style: none; margin: 0; padding: 0; display: grid; gap: 6px; }
.tglist li { display: flex; justify-content: space-between; align-items: center; gap: 8px; }
.tglist a { display: grid; text-decoration: none; min-width: 0; }
.gene { font: 700 var(--t-md)/1.1 ui-monospace, "SF Mono", Menlo, Consolas, monospace; color: var(--mol); letter-spacing: .02em; }
.tg-organ { margin-top: var(--s6); }
.tg-organ > .row-between { border-bottom: 2px solid var(--ink); padding-bottom: 6px; margin-bottom: 4px; }
.tg-grid { display: grid; grid-template-columns: repeat(auto-fill, minmax(260px, 1fr)); gap: var(--s4); margin-top: var(--s4); }
.tg-card { display: grid; gap: 6px; align-content: start; min-width: 0; overflow-wrap: anywhere; padding: var(--s4) var(--s5); border: 1px solid var(--line); border-radius: var(--r); background: var(--panel); box-shadow: var(--shadow);
  text-decoration: none; color: var(--ink); transition: transform .15s ease, box-shadow .15s ease, border-color .15s; }
.tg-card:hover { transform: translateY(-2px); border-color: var(--mol); box-shadow: 0 6px 20px rgba(15, 107, 107, .12); color: var(--ink); }
.tg-meta { display: flex; flex-wrap: wrap; justify-content: space-between; align-items: center; gap: 6px 12px; margin-top: 4px; padding-top: 8px; border-top: 1px solid var(--line-2); }
.plddt { display: inline-flex; align-items: center; gap: 6px; white-space: nowrap; }

.plddt .bar { width: 64px; height: 6px; border-radius: 3px; background: linear-gradient(90deg, #ff7d45 0 50%, #ffdb13 50% 70%, #65cbf3 70% 90%, #0053d6 90%); position: relative; overflow: hidden; }
.plddt .bar span { position: absolute; inset: -2px auto -2px 0; background: transparent; border-right: 2px solid var(--ink); }
.panel.mol .panel-head { flex-wrap: wrap; }
.panel.mol .panel-head h2 { flex: 1 1 260px; min-width: 0; }
.seg a { white-space: nowrap; }
.target-grid { display: grid; grid-template-columns: minmax(0, 1.1fr) minmax(0, 1fr); gap: var(--s5); margin-top: var(--s5); align-items: start; }
.target-grid .panel { min-width: 0; }
@media (max-width: 1280px) { .target-grid { grid-template-columns: minmax(0, 1fr); } }
.mol-view { position: relative; height: 460px; background: radial-gradient(circle at 50% 45%, #fff, #f1f5f8); border-bottom: 1px solid var(--line-2); }
.mol-canvas { position: absolute; inset: 0; }
.mol-canvas canvas { border-radius: 0; }
.mol-fallback { position: absolute; inset: 0; display: grid; place-items: center; padding: var(--s5); text-align: center; color: var(--ink-3); }
.plddt-legend, .panel.mol .legend { margin: 0; justify-content: flex-start; }
.legend .sw { width: 12px; height: 12px; border-radius: 3px; display: inline-block; }
button[data-spin][aria-pressed="true"] { background: var(--mol-wash); border-color: var(--mol); color: var(--mol); }

/* CMS codes, med-info, letter */
.codes { list-style: none; margin: 0; padding: 0; display: grid; gap: 8px; }
.codes li { padding: 8px 10px; border-radius: var(--r-sm); border: 1px solid var(--line-2); }
.codes li.yes { border-color: var(--clear); background: var(--clear-wash); }
.codes li.no { opacity: .7; }
.mireq.answered { border-left: 3px solid var(--clear); }
.letter { padding: var(--s7) var(--s7); max-width: 760px; line-height: 1.6; }
.letter ul { padding-left: 20px; }
@media (max-width: 1180px) { .chain { grid-template-columns: repeat(3, minmax(0, 1fr)); row-gap: var(--s4); } .chain li::after { display: none; } }
@media (max-width: 860px) { .chain { grid-template-columns: repeat(2, minmax(0, 1fr)); } .mol-view { height: 340px; } .letter { padding: var(--s5); } }
@media print {
  .side, .topbar, .disclaimer, .noprint, .toast { display: none !important; }
  .shell { display: block; } .content { padding: 0; } .letter { border: 0; box-shadow: none; max-width: none; padding: 0; }
}

/* personalised target priorities */
.prio { list-style: none; margin: 0; padding: 0; display: grid; gap: 10px; counter-reset: prio; }
.prio li { counter-increment: prio; padding-bottom: 10px; border-bottom: 1px solid var(--line-2); min-width: 0; }
.prio li:last-child { border-bottom: 0; padding-bottom: 0; }
.prio-row { display: grid; align-items: center; gap: 4px 10px; text-decoration: none; color: var(--ink); }
.prio-row::before { content: counter(prio); grid-row: span 1; width: 20px; height: 20px; border-radius: 50%; background: var(--mol-wash); color: var(--mol); font-size: var(--t-xs); font-weight: 700; display: grid; place-items: center; }
.prio-row { grid-template-columns: 20px auto minmax(0, 1fr) auto; }
.prio-row:hover .gene { text-decoration: underline; }
.prio-name { font-size: var(--t-sm); color: var(--ink-2); overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.prio-score { display: inline-flex; align-items: center; gap: 6px; font-size: var(--t-sm); }
.prio-score .bar { width: 64px; height: 6px; border-radius: 3px; background: var(--line-2); overflow: hidden; }
.prio-score .bar span { display: block; height: 100%; background: var(--mol); border-radius: 3px; }
.prio li > p { margin-top: 3px; padding-left: 30px; overflow-wrap: anywhere; }
.panel.personal { border-top: 3px solid var(--mol); }
.note.personal-note { background: var(--mol-wash); color: #0b4f4f; }
@media (max-width: 860px) { .prio-row { grid-template-columns: 20px auto minmax(0, 1fr); } .prio-score { grid-column: 2 / -1; } }

/* Insight Rx Copilot (Backboard memory) */
.copilot-panel { border-top: 3px solid var(--blue); }
.cp-turns { list-style: none; margin: 0 0 var(--s4); padding: 0; display: grid; gap: 10px; max-height: 520px; overflow-y: auto; }
.cp-turns li { padding: 10px 14px; border-radius: 12px; max-width: 92%; }
.cp-clinician { justify-self: end; background: var(--blue-wash); }
.cp-copilot { justify-self: start; background: var(--neutral-wash); }
.cp-who { display: block; font-size: var(--t-xs); font-weight: 700; color: var(--ink-3); margin-bottom: 2px; }
.cp-text { font-size: var(--t-sm); white-space: pre-wrap; overflow-wrap: anywhere; }
.cp-mem { display: flex; gap: 6px; align-items: flex-start; margin-top: 6px; font-size: var(--t-xs); color: var(--mol); }
.cp-prompts { display: flex; flex-wrap: wrap; gap: 6px; margin-bottom: 8px; }
.cp-chip { border: 1px solid var(--line); background: var(--panel); border-radius: 999px; padding: 5px 12px; font: inherit; font-size: var(--t-xs); cursor: pointer; color: var(--ink-2); }
.cp-chip:hover { border-color: var(--blue); color: var(--blue); }
.mems { list-style: none; margin: 0; padding: 0; display: grid; gap: 8px; }
.mems li { display: flex; justify-content: space-between; align-items: center; gap: 10px; padding: 8px 10px; border: 1px solid var(--line-2); border-radius: var(--r-sm); }